Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 30, 2017Basic & Clinical Pharmacology & ToxicologyOpen Access

The CYP2C19*2 and CYP2C19*17 Polymorphisms play a Vital Role in Clopidogrel Responsiveness after Percutaneous Coronary Intervention: A Pharmacogenomics Study

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Are CYP2C19 polymorphisms associated with clopidogrel responsiveness in patients undergoing percutaneous coronary intervention?

Population

347 Turkish patients who underwent percutaneous coronary interventions with stent implantation

Design

Cohort

Follow-up

at least 7 days

Authors

FSFaruk SaydamİDİrfan DeğirmenciABAlparslan Birdane

Discussion

Loading...

Member takes

Overview

May inform personalized antiplatelet selection post-PCI; leaves open need for outcome trials before routine genotyping.

Structured PICO

Are CYP2C19 polymorphisms associated with clopidogrel responsiveness in patients undergoing percutaneous coronary intervention?

P
Population
347 Turkish patients who underwent percutaneous coronary interventions with stent implantation
I
Intervention
Clopidogrel 75 mg/day for at least 7 days
O
Outcome
Platelet reactivity (PRU) and % inhibition measured with VerifyNow P2Y12 assaysurrogate

The CYP2C19*2 polymorphism is associated with clopidogrel non-responsiveness, whereas the CYP2C19*17 polymorphism enhances its antiplatelet activity in patients undergoing PCI.

Cite This Study

Saydam et al. (2017) studied this question.

synapsesocial.com/papers/6a7d5ea976c74e41c946d7ddhttps://doi.org/10.1111/bcpt.12763
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The <i>ABCB1</i> , <i>CYP2C19</i> , <i>CYP3A5</i> and <i>CYP4F2</i> genetic polymorphisms and platelet reactivity in the early phases of acute coronary syndromes2018 · 12 citations
  2. 2Genetic and nongenetic factors influencing the response to clopidogrel2013 · 24 citations
  3. 3Genotyping, Platelet Activation, and Cardiovascular Outcome in Patients after Percutaneous Coronary Intervention: Two Pieces of the Puzzle of Clopidogrel Resistance2017 · 14 citations
  4. 4Besides CYP2C19*2, the variant allele CYP2C9*3 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation2009 · 95 citations
  5. 5Genotyping of six clopidogrel-metabolizing enzyme polymorphisms has a minor role in the assessment of platelet reactivity in patients with acute coronary syndrome2017 · 3 citations