Why the study?
What are the pathologic abnormalities and putative mechanisms of radiation-induced heart disease in patients receiving chest radiation?
What are the pathologic abnormalities and putative mechanisms of radiation-induced heart disease in patients receiving chest radiation?
This review highlights the pathophysiologic mechanisms of radiation-induced heart disease, emphasizing tissue fibrosis as a central mediator, to inform future therapeutic development.
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May inform enhanced cardiac surveillance after chest radiation; leaves open targeted antifibrotic interventions for RIHD.
Taunk et al. (2015) studied this question.
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