Key result
Statins and ACE inhibitors show potential to prevent radiation-induced heart disease following thoracic radiotherapy.
Why the study?
Radiation-induced heart disease is a serious complication of radiation therapy for thoracic tumors, making it important to identify its mechanisms and propose preventive interventions.
Design
Review
Authors
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May warrant considering statins or ACE inhibitors for RIHD prevention in thoracic radiotherapy; leaves open need for prospective trials.
This review highlights the mechanisms and clinical manifestations of radiation-induced heart disease to aid clinicians in its identification and prevention.
Wang et al. (2019) conducted a review in Radiation-induced heart disease. Radiation-induced heart disease is a serious complication of thoracic radiotherapy driven by endothelial injury, oxidative stress, and inflammation, with statins and ACE inhibitors showing preventive potential.
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