Why the study?
Does dual-chamber pacing with closed loop stimulation reduce syncope burden and time to first recurrence in patients age ≥40 years with head-up tilt test-induced vasovagal syncope?
Does dual-chamber pacing with closed loop stimulation reduce syncope burden and time to first recurrence in patients age ≥40 years with head-up tilt test-induced vasovagal syncope?
Dual-chamber pacing with closed loop stimulation significantly reduces syncope burden and delays recurrence in older patients with tilt-induced vasovagal syncope.
Supports DDD-CLS pacing for tilt-induced vasovagal syncope in patients ≥40 years; challenges prior low-certainty evidence against benefit.
DDD-CLS pacing significantly reduced syncope burden and time to first recurrence by 7-fold, prolonging time to first syncope recurrence in patients age ≥40 years with head-up tilt test-induced vasovagal syncope compared with sham pacing. (Closed Loop Stimulation for Neuromediated Syncope [SPAIN Study]; NCT01621464).
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Barón‐Esquivias et al. (2017) studied this question.
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