January 13, 2012EP EuropaceOpen Access

Closed-loop cardiac pacing vs. conventional dual-chamber pacing with specialized sensing and pacing algorithms for syncope prevention in patients with refractory vasovagal syncope: results of a long-term follow-up

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Why the study?

Does dual-chamber closed-loop stimulation pacing reduce syncope recurrence in patients with refractory vasovagal syncope and a cardioinhibitory response compared to conventional dual-chamber pacing?

Population

41 patients with recurrent, refractory vasovagal syncope and a cardioinhibitory response to head-up tilt…

Comparison

Dual-chamber closed-loop stimulation pacemaker vs Dual-chamber pacemaker with conventional…

Design

Cohort

Follow-up

mean 4.4 ± 3.0 years

Authors

PPPietro PalmisanoElectrophysiology MZM. ZaccariaUniversidad de Zaragoza GLGiovanni LuzziAzienda Ospedaliera S.Giuseppe Moscati

Discussion

Member takes

Implication

CLS pacing was associated with lower syncope recurrence; hypothesis-generating and requires randomized confirmation before practice change.

Structured PICO

Does dual-chamber closed-loop stimulation pacing reduce syncope recurrence in patients with refractory vasovagal syncope and a cardioinhibitory response compared to conventional dual-chamber pacing?

Population

41 patients with recurrent, refractory vasovagal syncope (VVS) and a cardioinhibitory response to head-up tilt test (HUTT) who had undergone pacemaker implantation, mean age 53 ± 16 years, 44% male, 26% with trauma.

Intervention

Dual-chamber closed-loop stimulation (CLS) pacemaker

Comparator

Dual-chamber pacemaker with conventional algorithms for syncope prevention (Medtronic rate drop response algorithm or Guidant-Boston Scientific sudden brady response algorithm)

Outcome

Syncope recurrence during long-term follow-uphard clinical

Dual-chamber closed-loop stimulation pacing is significantly more effective than conventional pacing algorithms in preventing syncope recurrence in patients with refractory vasovagal syncope and a cardioinhibitory response.

Cite This Study

Palmisano et al. (2012) studied this question.

synapsesocial.com/papers/6a70ed2d8031ec7bb1dcab3f https://doi.org/10.1093/europace/eur419

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Implication

CLS pacing was associated with lower syncope recurrence; hypothesis-generating and requires randomized confirmation before practice change.

Closed-loop cardiac pacing vs. conventional dual-chamber pacing with specialized sensing and pacing algorithms for syncope prevention in patients with refractory vasovagal syncope: results of a long-term follow-up

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Closed-loop cardiac pacing vs. conventional dual-chamber pacing with specialized sensing and pacing algorithms for syncope prevention in patients with refractory vasovagal syncope: results of a long-term follow-up

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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