Does the '4-minus' haplotype of the NPR-A receptor gene affect NT-proBNP values in healthy individuals and patients with cardiovascular disorders?
Genetic variation in the NPR-A gene contributes to baseline differences in NT-proBNP levels among healthy individuals, which may be important for interpreting this biomarker.
The "4-minus" haplotype of the NPR-A receptor gene is associated with high NT-proBNP values and is a genetic determinant of the interindividual variability in the BNP system in healthy individuals but probably not in patients with cardiovascular disorders.
Weber et al. (Fri,) studied this question.