Why the study?
Does native low-density lipoprotein increase the generation of superoxide anion and nitric oxide in endothelial cells?
Does native low-density lipoprotein increase the generation of superoxide anion and nitric oxide in endothelial cells?
Native LDL increases endothelial cell production of superoxide anion and nitric oxide, likely promoting the formation of the potent oxidant peroxynitrite.
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Native LDL may promote endothelial peroxynitrite formation; leaves open relevance to human vascular disease.
Pritchard et al. (1995) studied this question.
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