Why the study?
Does native LDL at atherogenic concentrations down-regulate nitric oxide synthase expression in human endothelial cells?
Population
Human umbilical vein endothelial cells
Comparison
Human native low-density lipoproteins at… vs High-density lipoproteins at physiological…
Design
Preclinical
Follow-up
48 hours
Authors
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May link hypercholesterolemia to endothelial dysfunction; hypothesis-generating and requires human in vivo confirmation.
Does native LDL at atherogenic concentrations down-regulate nitric oxide synthase expression in human endothelial cells?
Atherogenic concentrations of native LDL down-regulate endothelial nitric oxide synthase expression, suggesting a mechanism by which hypercholesterolemia induces early endothelial changes in atherosclerosis.
Vidal et al. (1998) studied this question.
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