Sinoatrial Nodal Cell Ryanodine Receptor and Na + -Ca 2+ Exchanger
Population
Isolated sinoatrial nodal cells (SANCs)
Comparison
Ryanodine and acute blockade of the Na+-Ca2+… vs Baseline/unblocked state
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Requires validation before considering Ca2+-NCX targeting in humans; leaves open role in intact hearts.
Structured PICO
P
Population
Isolated sinoatrial nodal cells (SANCs)
I
Intervention
Ryanodine (sarcoplasmic reticulum Ca2+ release channel blocker) and acute blockade of the Na+-Ca2+ exchanger (via rapid substitution of bath Na+ by Li+)
C
Comparator
Baseline/unblocked state
O
Outcome
SANC beating rate, local Ca2+ transients, and inward current during diastolic depolarizationsurrogate
Ca2+ activation of the Na+-Ca2+ exchanger, driven by localized sarcoplasmic reticulum Ca2+ release, is a critical mechanism in generating the heartbeat and determining its rate.
Cite This Study
Bogdanov et al. (2001) studied this question.