Key Points
- Analyze current hypertension control rates in the United States, identify barriers to target blood pressure achievement, and evaluate interventions for resistant hypertension.
- Narrative review evaluating national epidemiological data on blood pressure control rates relative to Healthy People 2000 and 2010 goals.
- Synthesized evidence on contributing clinical risk factors, provider prescribing patterns, and patient adherence barriers.
- Assessed health system interventions, such as Veterans Administration initiatives, and emerging pharmacotherapies designed for resistant hypertension.
- Blood pressure control rates in the United States fail to meet national benchmarks despite improved awareness, driven by an aging demographic, kidney disease, obesity, high sodium intake, therapeutic inertia, and poor medication adherence.
- Resistant hypertension, defined as uncontrolled blood pressure despite adherence to a three-drug regimen including a diuretic, is projected to rise as the population ages.
- Structured health system protocols and novel targeted drug therapies demonstrate efficacy in lowering resistant hypertension rates and improving blood pressure goal attainment.
Structured PICO
PPopulationPatients with hypertension in the United States
Systemic efforts and new medications are needed to address the growing prevalence of resistant hypertension and improve overall blood pressure control in the US.