Why the study?
Are increased IL-1β levels associated with impaired myocardial function and left ventricular remodelling in patients following acute STEMI treated by primary PCI?
Are increased IL-1β levels associated with impaired myocardial function and left ventricular remodelling in patients following acute STEMI treated by primary PCI?
Elevated IL-1β levels following reperfused STEMI may serve as a predictor for maladaptive myocardial remodeling and impaired function at 1 year.
May flag high-risk STEMI patients for monitoring; leaves open whether IL-1β inhibition improves remodeling.
IL-1β levels after STEMI were strongly associated with impaired myocardial function and noninfarct LV mass after 1 year, suggesting a potential role for IL-1β as a predictor of maladaptive myocardial remodelling following reperfused MI.
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Ørn et al. (2012) studied this question.
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