Key result
Admission levels of serum MMP-9 positively correlated with left ventricular end-diastolic volume (r=0.294, p=0.022) at 3-year follow-up in patients with acute STEMI.
Why the study?
Do admission levels of serum inflammation factors correlate with left ventricular remodeling in patients with acute STEMI?
Observational (n=140)
Do admission levels of serum inflammation factors correlate with left ventricular remodeling in patients with acute STEMI?
Effect estimate: r=0.294
p-value: p=0.022
Admission levels of serum MMP-9 and TIMP-1 correlate with left ventricular structure and function at 3 years, suggesting involvement in post-infarction myocardial remodeling.
May aid post-STEMI remodeling risk stratification; leaves open causal role and need for prospective trials.
PURPOSE: To investigate the changes and correlations of the serum inflammation factors levels and left ventricular (LV) structure and function in patients with acute ST segment elevation myocardial infarction (STEMI). MATERIALS AND METHODS: A prospective study was performed on 70 STEMI patients and 70 control subjects. Serum levels of interleukin-6 (IL-6), soluble CD40 ligand (sCD40L), metalloproteinase- 9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were measured by sandwich enzyme-linked immunosorbent assay (ELISA), and cardiac structure and function were assessed by echocardiography at admission and 3-year follow-up. RESULTS: We found that the levels of serum IL-6, sCD40L and MMP-9 increased steadily among control subjects, remote myocardial infarction and acute STEMI patients, and the level of TIMP-1 elevated remarkly at 3-year follow-up visit in STEMI. The admission level of serum MMP-9 positively correlated with LV end-diastolic and end-diastole volume (r=0.294, p=0.022; r=0.269, p=0.036, respectively), and TIMP-1 positively correlated with E/A ratio (r=0.278, p=0.044) at 3-year follow-up. CONCLUSION: The study indicates that admission levels of serum MMP-9 and TIMP-1 closely correlated with left ventricular structure and function, which may be involved in the process of post-infarction remodeling of myocardium.
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Tan et al. (2012) conducted an observational in Acute ST segment elevation myocardial infarction (STEMI) (n=140). Serum inflammation factors (IL-6, sCD40L, MMP-9, TIMP-1) vs. Control subjects was evaluated on Correlation between admission serum MMP-9 and left ventricular end-diastolic volume at 3-year follow-up (r=0.294, p=0.022). Admission levels of serum MMP-9 positively correlated with left ventricular end-diastolic volume (r=0.294, p=0.022) at 3-year follow-up in patients with acute STEMI.
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