Why the study?
Are the calcium signaling pathway genes RUNX2 and CACNA1C associated with calcific aortic valve disease?
Are the calcium signaling pathway genes RUNX2 and CACNA1C associated with calcific aortic valve disease?
The identification of CACNA1C and confirmation of RUNX2 highlight the importance of the calcium signaling pathway in the genetic susceptibility to calcific aortic valve disease.
Supports calcium signaling in aortic stenosis; leaves open whether RUNX2 or CACNA1C informs risk or therapy.
This integrative genomic study confirmed the role of RUNX2 as a potential driver of AS and identified a new AS susceptibility gene, CACNA1C, belonging to the calcium signaling pathway.
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Guauque-Olarte et al. (2015) studied this question.
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