Recurrent Takotsubo cardiomyopathy can present with variable phenotypic patterns (e.g., reverse then classical apical) and highlights the importance of integrated multidisciplinary care in patients with psychiatric comorbidities.
Recurrent Takotsubo stabilization with multidisciplinary care; leaves open generalizability and optimal protocols for psychiatric comorbidities.
Takotsubo cardiomyopathy (TTC) is a transient stress-induced cardiac syndrome that can mimic acute coronary syndrome but typically lacks obstructive coronary disease. We report a case of a 50-year-old woman with complex psychiatric comorbidities who developed classical apical TTC following acute emotional distress-distinct from a prior reverse TTC episode during medical illness. Her condition stabilized with supportive care, anticoagulation, and psychiatric management. This case illustrates the phenotypic variability of TTC, the role of emotional stress in recurrence, and the importance of integrated multidisciplinary care.
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Alkowatli et al. (2025) studied this question.
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