Why the study?
Only a handful of case reports have highlighted multiple sclerosis as a trigger of reverse takotsubo syndrome.
Multiple sclerosis brainstem lesions can serve as a rare neurologic trigger for reverse Takotsubo syndrome leading to cardiogenic shock.
Prompts neurologic evaluation in unexplained reverse Takotsubo; leaves open broader prevalence and causality.
Our case is an example of the brain-heart relationship: it shows how neurologic inflammatory diseases can trigger a cardiogenic shock due to TTS, with potentially serious outcomes. It sheds light on the reverse form, which, although rare, has already been described in the setting of acute neurologic disorders. Only a handful of case reports have highlighted MS as a trigger of reverse TTS. Finally, through an updated systematic review, we highlight the unique features of patients with reversed TTS triggered by MS.
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Brandner et al. (2023) studied this question.
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