Why the study?
Various central nervous system diseases can lead to Takotsubo syndrome, prompting reporting of specific neuroinflammatory etiologies.
Multiple sclerosis should be considered as a potential trigger for Takotsubo syndrome, highlighting the importance of neurological workup in these patients.
Recurrent TTS with respiratory failure may signal brainstem MS; extends CNS triggers but remains hypothesis-generating.
Various central nervous system (CNS) diseases, including neurovascular and neuroinflammatory diseases, can lead to stress cardiomyopathy, also known as Takotsubo syndrome (TTS). We present a case of a 69-year-old woman with cardiovascular comorbidities, suffering from repeated episodes of TTS and respiratory failure due to a critical lesion in the brainstem, leading to a diagnosis of multiple sclerosis (MS). Despite aggressive treatment, intractable and recurrent symptoms in our patient occurred. Repeated bouts of autonomic dysfunction and respiratory failure ultimately led to installment of palliative care and the patient passing away. TTS should raise suspicion for underlying neurological diseases. Thorough questioning of previous neurological symptoms and extensive neurological workup is warranted. MS should be considered as a trigger of TTS also in elderly patients with cardiovascular risk factors.
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Risseeuw et al. (2021) studied this question.
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