Key result
Multiple sclerosis-associated takotsubo cardiomyopathy presents as basal variant in ~65% of cases, frequently involving medulla lesions.
Why the study?
The association between takotsubo cardiomyopathy and multiple sclerosis, particularly with brainstem involvement, requires increased awareness and systematic evaluation.
Systematic Review (n=20)
Takotsubo cardiomyopathy associated with multiple sclerosis frequently presents as the basal variant and is strongly linked to brainstem lesions involving the medulla oblongata.
Clinicians should consider medullary lesions when evaluating takotsubo in MS patients; extends observational data on basal-variant predominance but remains hypothesis-generating.
A 34-year-old transgender woman presented with ventricular tachycardia and was diagnosed with takotsubo cardiomyopathy. Further evaluation revealed an underlying diagnosis of multiple sclerosis (MS) with brainstem lesions that may have triggered takotsubo cardiomyopathy. In this report, we also systematically reviewed published cases of takotsubo cardiomyopathy and MS and found that basal type takotsubo cardiomyopathy was the most common, and most patients presented with brainstem involvement of MS. An awareness of these associations by physicians, along with multidisciplinary collaboration, may facilitate the early diagnosis and improve the prognosis of these patients.
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Yamanaka et al. (2024) conducted a systematic review in Takotsubo cardiomyopathy and Multiple Sclerosis (n=20). Multiple sclerosis was evaluated on Takotsubo cardiomyopathy variant and brainstem involvement. In patients with multiple sclerosis, takotsubo cardiomyopathy most commonly presented as the basal variant (65% of cases) and frequently involved lesions in the medulla oblongata.
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