Why the study?
Do Class III antiarrhythmic drugs inhibit IK.ACh in guinea pig atrial cells?
Do Class III antiarrhythmic drugs inhibit IK.ACh in guinea pig atrial cells?
Class III antiarrhythmic drugs inhibit IK.ACh in guinea pig atrial cells, providing a potential mechanistic basis for their use in atrial flutter and fibrillation.
May support mechanistic basis for Class III agents in AF; leaves open translation to human atrial electrophysiology.
Sotalol may inhibit IK.ACh by the blockade of the atrial muscarinic receptors, whereas E-4031 and MS-551 may inhibit the current not only by blocking the muscarinic receptors but also by depressing the function of the K+ channel itself and/or G proteins. These drugs may potentially be useful for the prevention and termination of atrial flutter and fibrillation through their inhibitory action on IK.ACh.
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Mori et al. (1995) studied this question.
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