Key result
E-4031 increases AF threshold in guinea pigs but is less potent than class I antiarrhythmics.
Why the study?
Does E-4031 improve atrial fibrillation threshold, effective refractory period, and interatrial conduction time in guinea pig hearts compared to class I antiarrhythmic agents?
Population
Langendorff-perfused guinea pig hearts perfused with Tyrode's solution containing acetylcholine (ACh 3 x 10 M)
Comparison
E-4031 (class III antiarrhythmic agent) vs Class I antiarrhythmic agents and baseline…
Design
Preclinical
Authors
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E-4031's ERP-mediated antifibrillatory action is less potent than class I agents in guinea pigs; leaves open class selection for human AF.
Does E-4031 improve atrial fibrillation threshold, effective refractory period, and interatrial conduction time in guinea pig hearts compared to class I antiarrhythmic agents?
In guinea pig hearts, E-4031 exerts an antifibrillatory effect by prolonging atrial ERP alone, but is less potent than class I drugs that also affect conduction time.
Inoue et al. (1994) studied Atrial fibrillation (experimental model). E-4031 vs. Class I agents (disopyramide, procainamide, lidocaine, and flecainide) was evaluated on Atrial fibrillation threshold (AFT), atrial effective refractory period (ERP), and interatrial conduction time (ACT). In guinea pig hearts, E-4031 increased atrial fibrillation threshold and prolonged atrial effective refractory period, but its antifibrillatory effect was less potent than class I antiarrhythmic drugs.
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