April 1, 1993Journal of Cardiovascular Pharmacology

Electrophysiologic Effects of a New Class III Antiarrhythmic Agent, E-4031, on Atrial Flutter, Atrial Refractoriness, and Conduction Delay in a Canine Sterile Pericarditis Model

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Why the study?

Does E-4031 alter atrial refractoriness and conduction delay in a canine sterile pericarditis model?

Population

12 dogs with sterile pericarditis

Comparison

E-4031 vs Baseline (before infusion)

Design

Preclinical

Authors

ASAkihiko ShimizuKagoshima University MKMuneshige KaibaraNagasaki University OCOsmar Antonio CenturiónUniversity of Nagasaki

Discussion

Member takes

Implication

Hypothesis-generating for IKr blockade in atrial tachyarrhythmias; leaves open clinical translation pending human trials.

Structured PICO

Does E-4031 alter atrial refractoriness and conduction delay in a canine sterile pericarditis model?

Population

12 dogs with sterile pericarditis

Intervention

E-4031 (initial dose 10 micrograms/kg/min/5 min followed by continuous infusion of 0.1 microgram/kg/min)

Comparator

Baseline (before infusion)

Outcome

Atrial effective refractory period (AERP) and maximum conduction delay (MCD) at short cycle lengthssurrogate

In a canine sterile pericarditis model, E-4031 prolonged atrial refractoriness and conduction delay at short cycle lengths, effectively interrupting atrial flutter and fibrillation.

Cite This Study

Shimizu et al. (1993) studied this question.

synapsesocial.com/papers/6a208889ee274fb2963e8961 https://doi.org/10.1097/00005344-199304000-00021

Topics

Persistent AF management Atrial fibrillation Pericardial disease

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Electrophysiologic Effects of a New Class III Antiarrhythmic Agent, E-4031, on Atrial Flutter, Atrial Refractoriness, and Conduction Delay in a Canine Sterile Pericarditis Model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Electrophysiologic Effects of a New Class III Antiarrhythmic Agent, E-4031, on Atrial Flutter, Atrial Refractoriness, and Conduction Delay in a Canine Sterile Pericarditis Model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider