Electrophysiological effects of E‐3753, a new antiarrhythmic drug, in guinea‐pig ventricular muscle
Why the study?
Does E-3753 alter electrophysiological properties in guinea-pig ventricular muscle?
Population
Guinea-pig papillary muscles (ventricular muscle fibres)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
E-3753 shows class Ic effects in guinea-pig ventricle; leaves open clinical translation and safety in humans.
Structured PICO
Does E-3753 alter electrophysiological properties in guinea-pig ventricular muscle?
P
Population
Guinea-pig papillary muscles (ventricular muscle fibres)
I
Intervention
E-3753 (10^-7 to 10^-4 M)
O
Outcome
Electrophysiological parameters including action potential amplitude, Vmax, action potential duration (APD), and effective refractory period (ERP)surrogate
E-3753 exhibits class Ic antiarrhythmic properties in guinea-pig ventricular muscle without class IV (calcium antagonist) effects.
Cite This Study
Delpón et al. (1989) studied this question.