Key result
Class I antiarrhythmics blocking diastolic sodium current inhibit guinea pig pulmonary vein automaticity.
Why the study?
The effects of class I antiarrhythmic drugs on the automaticity of pulmonary vein myocardium and their relation to diastolic sodium current blockade were unclear.
Population
Isolated guinea pig pulmonary vein myocardia
Comparison
Class I antiarrhythmic drugs with and without blockade of diastolic sodium current component
Design
Microelectrode and voltage clamp experimental study
Authors
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May indicate variable PV automaticity suppression among class I agents; leaves open clinical translation for AF.
Class I antiarrhythmic drugs that block the diastolic sodium current component inhibit the automaticity of the pulmonary vein myocardium in a preclinical model.
Irie et al. (2020) studied this question. Class I antiarrhythmic drugs was evaluated on Automaticity (firing frequency and rate of diastolic depolarization). Class I antiarrhythmic drugs that block the diastolic sodium current component (aprindine, flecainide, propafenone) inhibit the automaticity of the guinea pig pulmonary vein myocardium.
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