Key result
Class Ia antiarrhythmic drugs cibenzoline, disopyramide, and procainamide significantly inhibited DNP-induced ATP-sensitive potassium current by 95.5%, 77.8%, and 76.4% respectively.
Why the study?
Do antiarrhythmic drugs inhibit ATP-sensitive potassium currents in isolated guinea pig ventricular myocytes?
Population
Isolated guinea pig ventricular cells
Comparison
Seven different antiarrhythmic drugs vs 2,4-dinitrophenol (DNP) 50 μmol/L alone
Design
Preclinical
Authors
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May link Class Ia agents to hypoglycemia in animal models; leaves open human cardiac relevance.
Do antiarrhythmic drugs inhibit ATP-sensitive potassium currents in isolated guinea pig ventricular myocytes?
Class Ia antiarrhythmic drugs inhibit ATP-sensitive potassium currents in guinea pig ventricular cells at therapeutic concentrations, providing a potential mechanism for drug-induced hypoglycemia.
Wu et al. (1992) studied this question. Class I antiarrhythmic drugs vs. DNP alone was evaluated on Inhibition of DNP-induced outward current (IDNP). Class Ia antiarrhythmic drugs cibenzoline, disopyramide, and procainamide significantly inhibited DNP-induced ATP-sensitive potassium current by 95.5%, 77.8%, and 76.4% respectively.
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