Why the study?
Does cibenzoline inhibit diazoxide-activated ATP-sensitive K+ channels in guinea-pig ventricular cells?
Population
Guinea-pig ventricular cells
Design
Preclinical
Authors
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May explain antiarrhythmic effects via KATP inhibition in ventricular cells; leaves open human translation.
Does cibenzoline inhibit diazoxide-activated ATP-sensitive K+ channels in guinea-pig ventricular cells?
Cibenzoline inhibits ATP-sensitive K+ channels in guinea-pig ventricular cells at therapeutic concentrations, which may contribute to its antiarrhythmic properties.
Sato et al. (1993) studied this question.
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