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July 1, 1993British Journal of PharmacologyOpen Access

Antiarrhythmic drugs, clofilium and cibenzoline are potent inhibitors of glibenclamide‐sensitive K+ currents in Xenopus oocytes

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Population

Voltage-clamped follicle-enclosed Xenopus oocytes

Design

Preclinical

Authors

HSHidenari SakutaSelf-Defense Forces Central HospitalKOKoichi OkamotoKanazawa UniversityYWYasuhiro WatanabeKansai Medical University

Discussion

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Overview

May indicate off-target KATP blockade by these antiarrhythmics at therapeutic levels; leaves open clinical relevance in humans.

Structured PICO

P
Population
Voltage-clamped follicle-enclosed Xenopus oocytes
I
Intervention
Antiarrhythmic drugs (clofilium, cibenzoline, RS-2135, pirmenol, lorcainide, KW-3407, E-4031, MS-551, bretylium, N-acetylprocainamide)
O
Outcome
Inhibition of Y-26763-induced glibenclamide-sensitive K+ currentssurrogate

The antiarrhythmic drugs clofilium and cibenzoline potently block glibenclamide-sensitive K+ channels in Xenopus oocytes at concentrations comparable to therapeutic plasma levels.

Cite This Study

Sakuta et al. (1993) studied this question.

synapsesocial.com/papers/6a75b7616e15464cba6a40bfhttps://doi.org/10.1111/j.1476-5381.1993.tb13655.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduction of ischemic K+ loss and arrhythmias in rat hearts. Effect of glibenclamide, a sulfonylurea.1990 · 223 citations
  2. 2Barbiturates inhibit ATP‐K<sup>+</sup>channels and voltage‐activated currents in CRI‐G1 insulin‐secreting cells1991 · 36 citations
  3. 3Antiarrhythmic Effects of MS-551, a New Class III Antiarrhythmic Agent, on Canine Models of Ventricular Arrhythmia.1992 · 59 citations
  4. 4Phentolamine and yohimbine inhibit ATP‐sensitive K+ channels in mouse pancreatic β‐cells1990 · 129 citations