Key result
In guinea pig ventricular myocytes, glibenclamide inhibited cAMP-activated Cl- currents in a concentration-dependent manner with an IC50 of 24.5 to 37.9 μmol/L.
Why the study?
Does glibenclamide inhibit cardiac cAMP-activated Cl- conductance in guinea pig ventricular myocytes?
Population
Single guinea pig ventricular myocytes
Comparison
External glibenclamide (≥ 10 µmol/L) vs Stimulants alone
Design
Preclinical
Authors
Loading...
Hypothesis-generating for glibenclamide's cardiac ion channel effects in animals; leaves open translation to human electrophysiology.
Does glibenclamide inhibit cardiac cAMP-activated Cl- conductance in guinea pig ventricular myocytes?
Effect estimate: IC50 24.5 to 37.9 μmol/L
Glibenclamide inhibits cardiac cAMP-activated Cl- conductance in a concentration-dependent manner, antagonizing forskolin-induced action potential shortening.
Tominaga et al. (1995) studied Guinea pig ventricular myocytes (in vitro). Glibenclamide was evaluated on cAMP-activated Cl- current (IC50 24.5 to 37.9 μmol/L). In guinea pig ventricular myocytes, glibenclamide inhibited cAMP-activated Cl- currents in a concentration-dependent manner with an IC50 of 24.5 to 37.9 μmol/L.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: