Observational study reveals tissue factor expression correlates with vascular growth and clotting in pancreatic cancer, indicating its potential role in tumor progression.
TF expression occurs early in pancreatic neoplastic transformation and is associated with VEGF expression, increased microvessel density, and possibly clinical venous thromboembolism in pancreatic cancer. Prospective studies evaluating the role of TF in pancreatic cancer outcomes are warranted.
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Khorana et al. (2007) studied this question.
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