What question did this study set out to answer?

To review the mechanisms by which tissue factor regulates cellular properties, vascular endothelial growth factor expression, and angiogenesis.

January 1, 2001Thrombosis and Haemostasis

Tissue Factor – A Receptor Involved in the Control of Cellular Properties, Including Angiogenesis

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Authors

JCJiang ChenSuzhou Traditional Chinese Medicine Hospital ABAngelika BierhausHeidelberg University SSStephan SchiekoferSigmund Freud Privatuniversität Wien

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Implication

Mechanistic review uncovers tissue factor signaling pathways promoting angiogenesis in tumor models, indicating therapeutic targets in coagulation-dependent and independent cascades.

Key Points

To review the mechanisms by which tissue factor regulates cellular properties, vascular endothelial growth factor expression, and angiogenesis.
Narrative synthesis of molecular models evaluating tissue factor expression and signaling in cellular growth and vessel formation.
Evaluation of factor VIIa-dependent proteolytic cascades, proteinase-activated receptor activation, and downstream kinase signaling pathways.
Characterization of cytoplasmic domain interactions and phosphorylation-mediated cellular events.
Tissue factor expression upregulates vascular endothelial growth factor through both coagulation-dependent and coagulation-independent mechanisms, directly stimulating endothelial vessel formation.
Cellular signaling occurs via four pathways: factor VIIa-dependent factor Xa and thrombin generation activating PAR-1/PAR-2, direct factor VIIa-mediated MAP kinase activation, cytoplasmic domain proteolytic interactions, and ligand-independent cytoplasmic signaling.
Regulatory mechanisms directing phosphorylation of the tissue factor cytoplasmic domain remain incompletely defined.

Cite This Study

Chen et al. (2001) studied this question.

synapsesocial.com/papers/6a838563102dbb3176604fc6 https://doi.org/10.1055/s-0037-1616231

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Implication

Mechanistic review uncovers tissue factor signaling pathways promoting angiogenesis in tumor models, indicating therapeutic targets in coagulation-dependent and independent cascades.

Tissue Factor – A Receptor Involved in the Control of Cellular Properties, Including Angiogenesis

Discussion

Member takes

Implication

Key Points

Cite This Study

Tissue Factor – A Receptor Involved in the Control of Cellular Properties, Including Angiogenesis

Discussion

Member takes

Implication

Key Points

Cite This Study

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