Tissue Factor in Cardiovascular Diseases
Key result
Tissue factor expression and circulating levels are elevated in patients with cardiovascular risk factors, making its inhibition an attractive target for treating cardiovascular diseases.
Design
Review
Authors
Discussion
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Implication
Tissue factor inhibition remains investigational; leaves open whether targeting it improves cardiovascular outcomes.
Key Points
- To examine the regulation, cellular signaling, and pathogenic contributions of tissue factor in cardiovascular diseases, alongside emerging therapeutic inhibitors.
- Synthesized molecular mechanisms of tissue factor induction across endothelial cells, vascular smooth muscle cells, and monocytes.
- Evaluated intracellular signaling pathways (MAP kinases, PI3-kinase, protein kinase C) driving tissue factor expression.
- Reviewed therapeutic approaches targeting tissue factor, including monoclonal antibodies, inactivated factor VIIa, and recombinant tissue factor pathway inhibitor.
- Tissue factor levels are elevated in patients with cardiovascular risk factors (hypertension, diabetes, dyslipidemia, smoking) and acute coronary syndromes.
- Tissue factor accelerates atherosclerosis by stimulating thrombus formation and inducing the migration and proliferation of vascular smooth muscle cells.
- Direct inhibition using anti-tissue factor antibodies, site-inactivated factor VIIa, or recombinant pathway inhibitors provides targeted therapeutic potential for cardiovascular disease.
PICO
P
Population
Cardiovascular diseases
I
Intervention / Comparator
Tissue factor inhibition
Tissue factor plays a key role in the pathogenesis of atherosclerosis and thrombus formation, highlighting its potential as a therapeutic target in cardiovascular diseases.
Cite This Study
Steffel et al. (2006) conducted a review in Cardiovascular diseases. Tissue factor inhibition was evaluated. Tissue factor expression and circulating levels are elevated in patients with cardiovascular risk factors, making its inhibition an attractive target for treating cardiovascular diseases.