Cardiovascular risk factors are associated with the severity of aortic sclerosis in the elderly, suggesting a potential causal role in the pathogenesis of calcific aortic valve disease.
Gradient association is hypothesis-generating; prospective studies needed before considering risk factor modification in aortic sclerosis.
The prevalence of ASC and AS in people ≥65 years is similar to that reported in other regions. The gradient in the association of cardiovascular risk factors with the severity of ASC suggests that they may be causally implied in the pathogenesis of the disease.
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Ferreira‐González et al. (2012) studied this question.
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