Why the study?
Is combined milrinone and enteral metoprolol therapy feasible in patients with septic shock and cardiac depression?
Is combined milrinone and enteral metoprolol therapy feasible in patients with septic shock and cardiac depression?
Low-dose enteral metoprolol combined with phosphodiesterase inhibitors is feasible for septic myocardial depression, warranting further prospective trials.
May support exploration in select septic shock cases; leaves open prospective randomized confirmation before practice change.
Low doses of enteral metoprolol in combination with phosphodiesterase inhibitors are feasible in patients with septic shock and cardiac depression but no overt heart failure. Future prospective controlled trials on the use of beta blockers for septic cardiomyopathy and their influence on proinflammatory cytokines are warranted.
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Schmittinger et al. (2008) studied this question.
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