Key result
Pre-ischemic milrinone plus esmolol limits metabolic impairment and preserves LV function in preclinical model.
Why the study?
The effects of phosphodiesterase type III inhibition on myocardial metabolism and left ventricular function during ischemia in the presence of beta-blockade were examined.
Does pre-emptive administration of milrinone and/or esmolol improve left ventricular function and myocardial metabolism during ischemia and reperfusion in pigs?
Comparison
Milrinone vs esmolol vs both vs control (no drugs)
Design
Randomized controlled preclinical study
Follow-up
15 min ischemia followed by 60 min reperfusion
Authors
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Milrinone pre-treatment may lessen hemodynamic impairment during ischemia under beta-blockade without metabolic worsening; leaves open translation to clinical ischemia-reperfusion settings.
RCT (n=23)
randomized
Does pre-emptive administration of milrinone and/or esmolol improve left ventricular function and myocardial metabolism during ischemia and reperfusion in pigs?
Pre-emptive administration of milrinone combined with esmolol preserves left ventricular function and diminishes metabolic impairment during ischemia and reperfusion in a porcine model.
Sidi et al. (2008) conducted an RCT in ischemia and myocardial stunning (n=23). Milrinone and esmolol vs. No drugs, milrinone alone, or esmolol alone was evaluated on regional myocardial metabolism and global left ventricular function. Pre-emptive administration of milrinone combined with esmolol before ischemia diminished metabolic impairment and preserved left ventricular function in pigs.
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