Quality of Life in Heart Failure with Preserved Ejection Fraction: Importance of Obesity, Functional Capacity, and Physical Inactivity

Yogesh N.V. Reddy; Aruna Rikhi; Masaru Obokata; Sanjiv J. Shah; Gregory D. Lewis; Omar F. Abou-Ezzedine; Shannon M. Dunlay; Steven E. McNulty; Hrishikesh Chakraborty; Lynne W. Stevenson; Margaret M. Redfield; Barry A. Borlaug

doi:10.1002/ejhf.1788

March 9, 2020European Journal of Heart FailureOpen Access

Quality of Life in Heart Failure with Preserved Ejection Fraction: Importance of Obesity, Functional Capacity, and Physical Inactivity

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Key Points

To determine the relationship between obesity, functional capacity, physical inactivity, and health-related quality of life in patients with heart failure with preserved ejection fraction.
Analyzed pooled data from randomized clinical trials including RELAX (NCT00763867), NEAT-HFpEF (NCT02053493), and INDIE-HFpEF (NCT02742129).
Evaluated participant body mass index, daily physical activity, objective functional capacity measures, and disease-specific quality of life scores.
Elevated body mass index and sedentary behavior are strongly linked to reductions in functional capacity.
Impaired functional capacity and higher levels of obesity independently associate with worse disease-specific quality of life.

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Implication

Randomized trial analysis reveals key determinants of quality of life in heart failure with preserved ejection fraction, highlighting the impact of obesity, inactivity, and functional capacity.

Abstract

RELAX, NCT00763867; NEAT-HFpEF, NCT02053493; INDIE-HFpEF, NCT02742129.

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Reddy et al. (2020) studied this question.

synapsesocial.com/papers/69d572c775589c71d767e78c https://doi.org/10.1002/ejhf.1788

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Quality of Life in Heart Failure with Preserved Ejection Fraction: Importance of Obesity, Functional Capacity, and Physical Inactivity

Key Points

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Implication

Abstract

Discussion

Cite This Study

Quality of Life in Heart Failure with Preserved Ejection Fraction: Importance of Obesity, Functional Capacity, and Physical Inactivity

Key Points

No abstract yet

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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