To determine the relationship between obesity, functional capacity, physical inactivity, and health-related quality of life in patients with heart failure with preserved ejection fraction.
Analyzed pooled data from randomized clinical trials including RELAX (NCT00763867), NEAT-HFpEF (NCT02053493), and INDIE-HFpEF (NCT02742129).
Evaluated participant body mass index, daily physical activity, objective functional capacity measures, and disease-specific quality of life scores.
Elevated body mass index and sedentary behavior are strongly linked to reductions in functional capacity.
Impaired functional capacity and higher levels of obesity independently associate with worse disease-specific quality of life.