Why the study?
Does left atrial appendage closure affect cardiac functional and structural remodeling in patients with non-valvular atrial fibrillation?
Does left atrial appendage closure affect cardiac functional and structural remodeling in patients with non-valvular atrial fibrillation?
Left atrial appendage closure is associated with significant increases in LA size and LV filling pressure, indicating potential adverse cardiac remodeling.
LAAC may promote adverse remodeling in NVAF; hypothesis-generating and requires randomized confirmation before practice implications.
There were significant increases in LA size and LV filling pressure among NVAF patients after LAAC. These impacts of LAAC on cardiac functional and structural remodeling may have some clinical implications that need to be addressed in future studies.
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Phan et al. (2018) studied this question.
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