Exercise-Induced Changes in Bioactive Lipids Might Serve as Potential Predictors of Post-Exercise Hypotension. A Pilot Study in Healthy Volunteers

Figures

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  Figure 1. Flow chart of participant choice.

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  Figure 2. Time course of blood pressure and heart rate during exercise and control intervention, (A): Mean systolic blood pressure [mm Hg], (B): Mean diastolic blood pressure [mm Hg], (C): Heart rate [beats per minute, bpm]. Baseline values (BL) were determined at −60 min at both study days. Since it was not possible to perform measurements during ergometer cycling, there is a gap in the exercise intervention graph during this period, black: exercise intervention grey: sedentary control intervention; values are expressed as means ± SE, n = 18, EE: end of exercise. Corresponding values are indicated in Supplementary Table S1.

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  Figure 3. Relative changes in hematocrit compared to baseline in control (grey) and exercise intervention (black) at different time points in the early post-exercise period; *** p < 0.001 in comparison to the control intervention.

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  Figure 4. Time courses of the relative levels of arachidonic acid (A) and its metabolites ((B) HETEs, (C) DHETs and (D) prostaglandins) in plasma. Baseline (BL) values were determined at −60 min at both study days and were set as 1 for better comparison. Exercise (E) was performed between −30 min and 0 min. Since it was not possible to perform measurements during ergometer cycling, there is a gap in the exercise intervention graph during this period. black: exercise intervention grey: sedentary control intervention; values are expressed as mean fold change from baseline ± SE, ** p < 0.01 * p < 0.1 (Friedmann test with Conover-Test (post-hoc) Bonferroni-Holm corrected) significant difference vs. baseline value, # p < 0.05, ### p < 0.001 significant difference control vs exercise intervention at RP (Wilcoxon signed rank test for dependent samples), n = 18. Abbreviations: HETE: hydroxyeicosatetranoic acid; DHET: dihydroxyeicosatrienoic acid, PGE2: prostaglandin E2, TXB: thromboxane B, AA: arachidonic acid, EE: end of exercise; RP: reference point.

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  Figure 5. Pearson Correlation of 15-HETE plasma levels versus PEH; fold-change in 15-HETE plasma level (% decrease compared to baseline at 10 min after cessation of exercise) versus PEH.