Why the study?
Does Neuron-Derived Neurotrophic Factor (NDNF) ameliorate adverse cardiac remodeling in experimental myocardial infarction?
Does Neuron-Derived Neurotrophic Factor (NDNF) ameliorate adverse cardiac remodeling in experimental myocardial infarction?
NDNF shows potential in reducing adverse cardiac remodeling post-MI via enhanced myocyte survival and angiogenesis in experimental models.
Supports NDNF investigation in experimental MI; hypothesis-generating and should not yet change practice.
These data suggest that NDNF ameliorates adverse myocardial remodeling after MI by its abilities to enhance myocyte survival and angiogenesis in the heart through focal adhesion kinase/Akt-dependent mechanisms.
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Joki et al. (2015) studied this question.
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