Systematic review and meta-analysis reveals variable definitions and high prevalence of no-reflow in stroke patients, highlighting the need for standardized reperfusion criteria.
The definition of no-reflow varied substantially across studies, but it appears to be a common phenomenon. Some of the no-reflow cases may simply represent remaining vessel occlusions, and it remains unclear whether no-reflow is an epiphenomenon of the infarcted parenchyma or causes infarction. Future studies should focus on standardizing the definition of no-reflow with more consistent definitions of successful macrovascular reperfusion and experimental set-ups that could detect the causality of the observed findings.
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Mujanović et al. (2023) studied this question.
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