Is preeclampsia associated with an increased risk of congenital heart defects in offspring?
Preeclampsia is associated with a significantly increased relative risk of congenital heart defects in offspring, although the absolute risk remains low.
In this population-based study, preeclampsia was significantly associated with noncritical heart defects in offspring, and preeclampsia before 34 weeks was associated with critical heart defects. However, the absolute risk of congenital heart defects was low.
Auger et al. (Tue,) studied this question.