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October 19, 2015Paediatric and Perinatal Epidemiology

Possible Common Aetiology behind Maternal Preeclampsia and Congenital Heart Defects in the Child: a Cardiovascular Diseases in N orway Project Study

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Why the study?

Does maternal preeclampsia increase the risk of severe congenital heart defects in offspring?

Population

914,703 singleton births without chromosomal abnormalities registered in the Medical Birth Registry of Norway

Comparison

Maternal preeclampsia vs Births without maternal preeclampsia

Design

Cohort

Authors

KBKristoffer BrodwallELElisabeth LeirgulGGGottfried Greve

Discussion

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Member takes

Overview

May warrant enhanced fetal echocardiography surveillance; leaves open causality and screening guidelines pending prospective studies.

Structured PICO

Does maternal preeclampsia increase the risk of severe congenital heart defects in offspring?

P
Population
914,703 singleton births without chromosomal abnormalities registered in the Medical Birth Registry of Norway (1994-2009)
I
Intervention
Maternal preeclampsia (including early-onset preeclampsia diagnosed before the 34th week of pregnancy)
C
Comparator
Births without maternal preeclampsia
O
Outcome
Severe congenital heart defects (CHD) in the offspringhard clinical

Early-onset maternal preeclampsia is strongly associated with an increased risk of severe congenital heart defects in offspring, particularly atrioventricular septal defects, suggesting shared etiological factors.

Cite This Study

Brodwall et al. (2015) studied this question.

synapsesocial.com/papers/6a8bcc4b3fd21775a533bba4https://doi.org/10.1111/ppe.12252
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Also Consider

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  1. 1A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects2001 · 244 citations
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  3. 3Prospective Study of Placental Angiogenic Factors and Maternal Vascular Function Before and After Preeclampsia and Gestational Hypertension2010 · 361 citations
  4. 4Circulating Angiogenic Factors and the Risk of Preeclampsia2004 · 3,649 citations
  5. 5Seeking causes: Classifying and evaluating congenital heart defects in etiologic studies2007 · 471 citations