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November 15, 2022JAMA Network OpenOpen Access

Association of Maternal Preeclampsia With Offspring Risks of Ischemic Heart Disease and Stroke in Nordic Countries

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Why the study?

An association between maternal preeclampsia and increased offspring cardiovascular risk is plausible, but evidence remains limited.

Does maternal preeclampsia increase the risk of ischemic heart disease and stroke in offspring?

Population

8 475 819 live singleton births from Danish, Finnish, and Swedish national registries

Comparison

Maternal preeclampsia vs unexposed

Design

Multinational population-based cohort study

Follow-up

Median 19.3 years

Authors

FYFen YangIJImre JanszkyMGMika Gissler

Discussion

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Member takes

Overview

I need the paper’s full results and key finding before writing the implication. Searching now.Opening the paper and PubMed abstract for the primary endpoint, effect sizes, and authors’ interpretation.PMC full text is available — pulling results, HRs, and the authors’ conclusions.Should not yet change offspring screening; leaves open whether preeclampsia is causal or a familial marker.

Structured PICO

Does maternal preeclampsia increase the risk of ischemic heart disease and stroke in offspring?

P
Population
8,475,819 live singleton births from Denmark (1973-2016), Finland (1987-2014), and Sweden (1973-2014), comprising 51.3% boys.
I
Intervention
Maternal preeclampsia (including subtypes: early onset <34 weeks, late onset ≥34 weeks, severe, mild/moderate, and with/without small for gestational age birth)
C
Comparator
No maternal preeclampsia
O
Outcome
Diagnoses of ischemic heart disease (IHD) and stroke extracted from patient and cause-of-death registershard clinical

Maternal preeclampsia is associated with a significantly increased long-term risk of ischemic heart disease and stroke in offspring, with severe forms conferring the highest risk.

Limitations

  • Associations were partially explained by unmeasured familial factors based on sibling analyses

Cite This Study

Yang et al. (2022) studied this question.

synapsesocial.com/papers/6a7ffb152cf87dafd7c85d84https://doi.org/10.1001/jamanetworkopen.2022.42064
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Possible Common Aetiology behind Maternal Preeclampsia and Congenital Heart Defects in the Child: a Cardiovascular Diseases in N orway Project Study2015 · 73 citations
  2. 2Cardiovascular morbidity and mortality after preeclampsia: A nationwide case-cohort study2026 · 1 citations
  3. 3Incident Coronary Heart Disease After Preeclampsia: Role of Reduced Fetal Growth, Preterm Delivery, and Parity2017 · 110 citations
  4. 4ABSTRACT NUMBER: ESOC2026A119 RISK FACTORS FOR STROKE IN PATIENTS WITH PREECLAMPSIA – A POPULATION-BASED STUDY2026
  5. 5Preeclampsia and the Long-Term Risk of Ischemic and Hemorrhagic Stroke: A Systematic Review and Analysis of Population-Based Studies2025