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May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026a119 Risk Factors for Stroke in Patients With Preeclampsia – A Population-Based Study

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Key result

DVT/PE is linked to a ~13-fold higher stroke risk in preeclampsia, alongside severe and recurrent disease.

  • OR 12.77
  • 95% CI 3.07-53.12
  • n=1,730

Why the study?

Stroke is the leading cause of maternal death in preeclampsia, but factors contributing to stroke risk in preeclamptic patients are poorly documented.

Comparison

Preeclamptic patients with stroke vs preeclamptic patients without stroke

Design

Retrospective case-control study

Authors

TVTeresa VestLVLiisa VerhoEKEija Kortelainen

Discussion

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Overview

May guide heightened vigilance in high-risk preeclamptic pregnancies; leaves open causality and preventive interventions pending RCTs.**[[1]](https://pubmed.ncbi.nlm.nih.

Key Points

  • This study investigates the risk factors contributing to stroke in preeclamptic patients.
  • Retrospective case-control design with 55 preeclamptic stroke patients and 1,675 controls from healthcare registers.
  • Stroke cases identified from the Stroke in Pregnancy and Puerperium cohort between 1987-2016; controls recruited from Finnish Genetics of Preeclampsia Consortium.
  • Clinical data collected from medical records to verify diagnoses.
  • Advanced maternal age was associated with increased stroke risk (OR 1.07, 95% CI 1.02-1.13).
  • Multiparity and recurrent preeclampsia demonstrated strong associations with stroke (OR 2.30, 1.30-4.09 and OR 2.18, 1.17-4.07, respectively).
  • Higher peak systolic blood pressure observed in cases (183 mmHg vs 165 mmHg; OR 1.036, 1.022–1.050).

Study Design

Type

Case-Control (n=1,730)

Multicenter

Yes

PICO

P
Population
Preeclampsia (n=1,730)
I
Intervention / Comparator
Risk factors (including severe preeclampsia, DVT/PE, multiparity) vs Preeclamptic patients without stroke
O
Primary Outcome
Stroke — OR 12.77 (3.07-53.12)

Main Result

Effect estimate: OR 12.77 (95% CI 3.07-53.12)

Cite This Study

Vest et al. (2026) conducted a case-control in Preeclampsia (n=1,730). Risk factors (including severe preeclampsia, DVT/PE, multiparity) vs. Preeclamptic patients without stroke was evaluated on Stroke (OR 12.77, 95% CI 3.07-53.12). Severe preeclampsia (100% vs 70.5%, p<0.001), DVT/PE (OR 12.77), multiparity (OR 2.30), and recurrent preeclampsia (OR 2.18) were identified as significant risk factors for stroke in preeclampsia.

synapsesocial.com/papers/69fd7ef7bfa21ec5bbf0754chttps://doi.org/10.1093/esj/aakag023.191
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Preeclampsia and the Long-Term Risk of Ischemic and Hemorrhagic Stroke: A Systematic Review and Analysis of Population-Based Studies2025
  2. 2Preeclampsia and the Risk of Ischemic Stroke Among Young Women2006 · 166 citations
  3. 3Association of Preeclampsia With Incident Stroke in Later Life Among Women in the Framingham Heart Study2021 · 52 citations
  4. 4Association of Maternal Preeclampsia With Offspring Risks of Ischemic Heart Disease and Stroke in Nordic Countries2022 · 48 citations
  5. 5Etiology and risk factors of ischemic stroke during pregnancy and puerperium: A population-based study2023 · 20 citations