Nr4a1 plays a crucial role in regulating the inflammatory and reparative functions of Ly-6C(high) monocytes following myocardial infarction.
Ly-6C(high) monocytes orchestrate both inflammatory and reparative phases during myocardial infarction and depend on Nr4a1 to limit their influx and inflammatory cytokine expression.
Hilgendorf et al. (Fri,) studied this question.