Nr4a1 plays a crucial role in regulating the inflammatory and reparative functions of Ly-6C(high) monocytes following myocardial infarction.
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Should not yet inform MI management; leaves open Nr4a1 as a monocyte regulator for future translational studies.
Ly-6C(high) monocytes orchestrate both inflammatory and reparative phases during myocardial infarction and depend on Nr4a1 to limit their influx and inflammatory cytokine expression.
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Hilgendorf et al. (2014) studied this question.
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