September 30, 2014HypertensionOpen Access

Nebivolol, But Not Metoprolol, Lowers Blood Pressure in Nitric Oxide–Sensitive Human Hypertension

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Why the study?

Does nebivolol decrease blood pressure in autonomic failure patients with supine hypertension through a mechanism independent of β-blockade?

Structured PICO

Does nebivolol decrease blood pressure in autonomic failure patients with supine hypertension through a mechanism independent of β-blockade?

Population

20 autonomic failure patients with supine hypertension, mean age 69±2 years, 14 men.

Intervention

Single oral dose of nebivolol 5 mg administered at night.

Comparator

Single oral dose of placebo, metoprolol 50 mg (negative control), and sildenafil 25 mg (positive control) administered on separate nights in a crossover design.

Outcome

Supine systolic blood pressure during the night (monitored every 2 hours from 8:00 pm to 8:00 am).surrogate

Nebivolol effectively lowers supine hypertension in autonomic failure patients independent of β1-blockade, supporting the hypothesis that nitric oxide potentiation contributes significantly to its antihypertensive effect.

Discussion

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Implication

Nebivolol lowers nocturnal BP in autonomic failure; confirms effect independent of β1-blockade.

Cite This Study

Okamoto et al. (2014) studied this question.

synapsesocial.com/papers/69d575f4c928a9acfd89a2e1 https://doi.org/10.1161/hypertensionaha.114.04116

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Nebivolol, But Not Metoprolol, Lowers Blood Pressure in Nitric Oxide–Sensitive Human Hypertension

Structured PICO

Discussion

Implication

Cite This Study

Topics

Nebivolol, But Not Metoprolol, Lowers Blood Pressure in Nitric Oxide–Sensitive Human Hypertension

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider