A Comparison of Immediate Angioplasty with Thrombolytic Therapy for Acute Myocardial Infarction
Why the study?
Does immediate PTCA reduce the combined occurrence of nonfatal reinfarction or death in patients with acute myocardial infarction compared with t-PA therapy?
Population
Patients with acute myocardial infarction
Comparison
Immediate PTCA vs t-PA (tissue plasminogen activator) therapy
Authors
Discussion
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Member takes
Implication
Supports immediate PTCA over t-PA in acute MI; confirms randomized superiority for reducing reinfarction, death, and hemorrhage.
Structured PICO
Does immediate PTCA reduce the combined occurrence of nonfatal reinfarction or death in patients with acute myocardial infarction compared with t-PA therapy?
P
Population
Patients with acute myocardial infarction
I
Intervention
Immediate PTCA (percutaneous transluminal coronary angioplasty)
C
Comparator
t-PA (tissue plasminogen activator) therapy
O
Outcome
Combined occurrence of nonfatal reinfarction or deathcomposite
Immediate PTCA provides better clinical outcomes than t-PA therapy for acute myocardial infarction by reducing reinfarction, death, and intracranial hemorrhage.
Cite This Study
Grines et al. (1993) studied this question.