What question did this study set out to answer?

To review the pathophysiological mechanisms, diagnostic criteria, long-term disease risks, and therapeutic considerations associated with metabolically healthy obesity.

March 4, 2020Endocrine ReviewsOpen Access

Metabolically Healthy Obesity

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To review the pathophysiological mechanisms, diagnostic criteria, long-term disease risks, and therapeutic considerations associated with metabolically healthy obesity.
Synthesized physiological and epidemiological evidence evaluating adipose tissue distribution, cardiorespiratory fitness, and cardiometabolic comorbidities in obesity phenotypes.
Characterized diagnostic parameters defining metabolic health, focusing on glycemic control, lipid profiles, and blood pressure.
Metabolically healthy obesity is characterized biologically by reduced ectopic fat deposition in visceral and liver tissues, preserved insulin sensitivity and beta-cell function, expanded subcutaneous fat capacity, and superior cardiorespiratory fitness relative to unhealthy obesity.
Individuals with metabolically healthy obesity exhibit elevated long-term risks of cardiovascular disease and type 2 diabetes compared to healthy lean individuals, and frequently transition over time into an unhealthy obese state.

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Implication

Narrative review reveals transient cardiometabolic protection in metabolically healthy obesity, highlighting the persistent need for risk-stratified weight-loss interventions.

Cite This Study

Matthias Blüher (2020) studied this question.

synapsesocial.com/papers/69d576af62196bac97d9bc19 https://doi.org/10.1210/endrev/bnaa004

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Implication

Narrative review reveals transient cardiometabolic protection in metabolically healthy obesity, highlighting the persistent need for risk-stratified weight-loss interventions.

Metabolically Healthy Obesity

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Discussion

Implication

Cite This Study

Metabolically Healthy Obesity

Key Points

Discussion

Implication

Cite This Study

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