Key result
Metabolically healthy obesity lacks standard diagnostic criteria, complicating research on prevalence and outcomes.
Why the study?
There are no single criteria for identifying individuals with metabolically healthy obesity, complicating study and comparative analysis of this subgroup.
This review highlights the concept of metabolically healthy obesity, noting the lack of standardized diagnostic criteria and discussing its mechanisms and therapeutic implications.
Inconsistent criteria for metabolically healthy obesity hinder reliable clinical classification; leaves open the need for consensus definitions to enable comparable research.
The prevalence of obesity is growing all over the world. Obesity is an important risk factor for cardiovascular diseases, type 2 diabetes. However, not all obese patients have an unfavorable cardio-metabolic profile. Recently, much attention has been paid to the concept of «metabolically healthy obesity» (MHO). To date, there are no single criteria for identifying individuals with MHO, which makes it difficult to study this subgroup of patients and to conduct a comparative analysis of various studies. The article presents data of modern literature, including the definition, prevalence and mechanisms of MHO development, also discusses potentially protective factors involved in MHO development and the consequences of the therapeutic impact on MHO.
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Волкова et al. (2017) conducted a review in Metabolically healthy obesity. Metabolically healthy obesity was evaluated. Metabolically healthy obesity lacks standardized diagnostic criteria, complicating comparative research on its prevalence, mechanisms, and therapeutic outcomes.
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