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The study aimed to document clinical characteristics and hospital outcomes for children with Down syndrome diagnosed with heart disease.

April 8, 2026PLoS ONEOpen Access

Clinical profile and hospital outcomes of children with Down syndrome diagnosed with congenital heart disease in a developing country: A retrospective study

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The study aimed to document clinical characteristics and hospital outcomes for children with Down syndrome diagnosed with heart disease.
Retrospective descriptive study of children with Down syndrome at Jakaya Kikwete Cardiac Institute from December 2022 to December 2024.
Extracted socio-demographics, clinical characteristics, and survival data from medical records.
Calculated frequencies, proportions, mean with standard deviation, and median with interquartile range for data analysis.
Data from 104 children with Down syndrome were analyzed from 1,356 admissions.
93.2% of children were aged below 5 years, with 58% being male.
Most common cardiac diagnoses were AVSD (46.2%) and VSD (14.4%) with a median diagnosis age of 5 months.
19.2% had prolonged hospital stays over 2 weeks, and 7.7% died during hospitalization.
4.8% underwent open cardiac surgery during the study period.

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Retrospective study highlights treatment outcomes in children with Down syndrome and congenital heart defects, suggesting improved care protocols.

Kalezi et al. (2026) studied this question.

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Retrospective study highlights treatment outcomes in children with Down syndrome and congenital heart defects, suggesting improved care protocols.