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April 8, 2026PLoS ONEOpen Access

The burden and correlates of bloodborne pathogens in a Zambian Blood Donor Cohort

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Authors

MMMwila MapipoAMAlex MaletiPMPhinnoty Mwansa

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Overview

Cross-sectional study identifies high prevalence of infections in blood donors, suggesting urgent safety improvements.

Key Points

  • This study investigates the prevalence and factors associated with bloodborne pathogens in blood donors.
  • Conducted a cross-sectional analysis of 2,667 blood donor records.
  • Collected data on demographics, donation type, and ABO/Rhesus blood group.
  • Screened for Hepatitis B, Hepatitis C, HIV, and Syphilis using the Abbott Alinity i platform.
  • Used logistic regression to identify factors related to infection status.
  • Overall prevalence of transfusion-transmitted infections (TTIs) was 25.7%.
  • Most prevalent infections were HBV (8.0%), Syphilis (8.0%), HCV (7.8%), and HIV (7.7%).
  • Blood group O showed 36% lower odds of any TTI compared to blood group A.
  • Individuals aged ≥45 had 45% higher odds of TTIs compared to those aged 16–24.
  • Distinct risk profiles identified for each pathogen based on demographic factors.

Cite This Study

Mapipo et al. (2026) studied this question.

synapsesocial.com/papers/69d5f07d74eaea4b11a79e2ehttps://doi.org/10.1371/journal.pone.0346680
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