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April 8, 2026Circulation Cardiovascular Imaging4 citationsOpen Access

Quantitative Coronary Atherosclerotic Plaque Burden From CCTA and the Benefit From Lipid-Lowering Medication

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TMTeemu MaaniittySBSarah BärJBJeroen J. Bax

Key Points

  • This research examines the effects of lipid-lowering medication (LLM) on adverse events in patients with coronary atherosclerotic plaque burden.
  • Analyzed symptomatic patients with suspected coronary artery disease (CAD)
  • Utilized coronary computed tomography angiography (CCTA) for assessment
  • Followed up long-term to evaluate adverse events in relation to plaque burden and treatment type
  • Patients with plaque area volume (PAV) greater than 5% experienced fewer adverse events after receiving LLM
  • Benefits of LLM were noted even without the presence of obstructive CAD

Abstract

In symptomatic patients with suspected CAD, LLM after coronary computed tomography angiography was associated with a lower rate of adverse events during long-term follow-up among those with PAV >5%, even in the absence of obstructive CAD. The quantification of coronary atherosclerotic plaque burden is a potential marker to guide preventive lipid-lowering therapy.

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Cite This Study

Maaniitty et al. (2026) studied this question.

synapsesocial.com/papers/69d5f09e74eaea4b11a7a07fhttps://doi.org/10.1161/circimaging.125.018840
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