Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 17, 2025DiagnosticsOpen Access

Longitudinal Effects of Lipid-Lowering Treatment on High-Risk Plaque Features and Pericoronary Adipose Tissue Attenuation Using Serial Coronary Computed Tomography

View Full Paper
Ask AI
Bookmark
Share

Authors

LWLoris WeichselFAFlorian AndréMRMatthias Renker

Discussion

Loading...

Member takes

Overview

Retrospective analysis shows lipid-lowering treatment improves high-risk plaque features in CAD patients, indicating potential clinical benefits.

Key Points

  • High-intensity lipid-lowering treatment regressed high-risk plaque features more effectively than low or no treatment.
  • Mean plaque feature score regression was observed with a hazard ratio of 4.6, indicating significant treatment effects.
  • Decreases in pericoronary adipose tissue were noted with higher treatment intensities, but no correlation was found with plaque volumes.
  • Baseline PCAT predicts high-risk plaque progression, emphasizing the importance of monitoring adipose tissue in CAD patients.

Cite This Study

Weichsel et al. (2025) studied this question.

synapsesocial.com/papers/68d45e4431b076d99fa5e366https://doi.org/10.3390/diagnostics15182340
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Assessing the Impact of Long-term High-Dose Statin Treatment on Pericoronary Inflammation and Plaque Distribution - a Comprehensive Coronary CTA Follow-up Study2024 · 6 citations
  2. 2Assessing the Impact of Long-Term High-Dose Statin Treatment on Pericoronary Inflammation and Plaque Distribution—A Comprehensive Coronary CTA Follow-Up Study2024 · 27 citations
  3. 3Peri-coronary adipose tissue attenuation and its association with plaque vulnerability and clinical outcomes in coronary artery disease using combined CCTA and OCT2025 · 7 citations
  4. 4Effect of coronary calcium-informed statin therapy on peri-coronary adipose tissue attenuation in intermediate-risk patients: post-hoc analysis of the CAUGHT-CAD randomised-controlled trial2025 · 1 citations
  5. 5Assessing the impact of long-term high-dose statin treatment on perivascular inflammation and plaque distribution - a comprehensive coronary CTA follow-up study2024